Register for updates

 
 

Biology & Evolution
RSS Feed
Make Like a Squid and Transform
Thursday, February 12, 2015 9:30:00 AM

TAU researcher discovers that squid recode their genetic make-up on-the-fly to adjust to their surroundings

The principle of adaptation — the gradual modification of a species' structures and features — is one of the pillars of evolution. While there exists ample evidence to support the slow, ongoing process that alters the genetic makeup of a species, scientists could only suspect that there were also organisms capable of transforming themselves ad hoc to adjust to changing conditions.

Now a new study published in eLife by Dr. Eli Eisenberg of Tel Aviv University's Department of Physics and Sagol School of Neuroscience, in collaboration with Dr. Joshua J. Rosenthal of the University of Puerto Rico, showcases the first example of an animal editing its own genetic makeup on-the-fly to modify most of its proteins, enabling adjustments to its immediate surroundings. The research, conducted in part by TAU graduate student Shahar Alon, explored RNA editing in the Doryteuthis pealieii squid.

"We have demonstrated that RNA editing is a major player in genetic information processing rather than an exception to the rule," said Dr. Eisenberg. "By showing that the squid's RNA-editing dramatically reshaped its entire proteome — the entire set of proteins expressed by a genome, cell, tissue, or organism at a certain time — we proved that an organism’s self-editing of mRNA is a critical evolutionary and adaptive force." This demonstration, he said, may have implications for human diseases as well.

Using the genetic red pencil

RNA is a copy of the genetic code that is translated into protein. But the RNA "transcript" can be edited before being translated into protein, paving the way for different versions of proteins. Abnormal RNA editing in humans has been observed in patients with neurological diseases. The changing physiological appearance of squid and octopuses over their lifetime and across different habitats has suggested extensive recoding might occur in these species. However, this could never be confirmed, as their genomes (and those of most species) have never been sequenced.

For the purpose of the new study, the researchers extracted both DNA and RNA from squid. Harnessing DNA sequencing and computational analyses at TAU, the team compared the RNA and DNA sequences to observe differences. The sequences in which the RNA and DNA did not match up were identified as "edited."

"It was astonishing to find that 60 percent of the squid RNA transcripts were edited. The fruit fly, for the sake of comparison, is thought to edit only 3% of its makeup," said Dr. Eisenberg. "Why do squid edit to such an extent? One theory is that they have an extremely complex nervous system, exhibiting behavioral sophistication unusual for invertebrates. They may also utilize this mechanism to respond to changing temperatures and other environmental parameters."

"Misfolding" the proteins

The researchers hope to use this approach to identify recoding sites in other organisms whose genomes have not been sequenced.

"We would like to understand better how prevalent this phenomenon is in the animal world. How is it regulated? How is it exploited to confer adaptability?" said Dr. Eisenberg. "There may be implications for us as well. Human diseases are often the result of 'misfolded' proteins, which often become toxic. Therefore the question of treating the misfolded proteins, likely to be generated by such an extensive recoding as exhibited in the squid cells, is very important for future therapeutic approaches. Does the squid have some mechanism we can learn from?"

The researchers recently received an Israel-U.S. Binational Science Foundation grant to explore the subject of genetic editing in octopuses.




Latest News

Egyptian Fruit Bats Trade Food for Sex

Female scroungers form bonds with particular male producers and exchange mating for nourishment, TAU researchers say.

Law Prof. Ariel Porat Named New President of Tel Aviv University

Former Dean of TAU's Buchmann Faculty of Law is an EMET Prize Laureate.

Major Violent Attacks Against Jews Spiked 13% Worldwide in 2018

U.S. had more than 100 cases of severe violence, annual TAU Kantor Center study reports.

New Reading of the Mesha Stele Inscription Has Major Consequences for Biblical History

Line of the inscription lends credence to the story of Balaam in the Book of Numbers, TAU researchers say.

TAU Study Paves Way for Innovative Treatment of Epilepsy

Researchers solve puzzle about brain activity regulation; breakthrough may lead to development of new, effective drugs to suppress seizures.

Hypersociability in Williams Syndrome Result of Myelination Deficits

Axon "insulating tape" suffers from gene deletion that causes social impairment associated with rare disorder, TAU researchers say.

LocalTAU Tackles Florida Stormwater Runoff in Inaugural Pitch Competition

Top scientific teams from Israel's leading university pitch novel solutions to local crisis.

TAU Scientists Print First 3D Heart Using Patient’s Own Cells and Materials

Engineered heart completely matches the immunological, cellular, biochemical and anatomical properties of the patient.

contentSecondary
c

© 2019 American Friends of Tel Aviv University
39 Broadway, Suite 1510 | New York, NY 10006 | 212.742.9070 | info@aftau.org
Privacy policy | Tel Aviv University