Register for updates

 
 

Medicine & Health
RSS Feed
New Antibacterial Fillings from TAU May Combat Recurring Tooth Decay
Tuesday, July 09, 2019 9:00:00 AM

Novel material may prevent one of the costliest and most prevalent bacterial diseases in the world

Tooth decay is among the costliest and most widespread bacterial diseases. Virulent bacteria cause the acidification of tooth enamel and dentin, which, in turn, causes secondary tooth decay.

A new study by Tel Aviv University researchers finds potent antibacterial capabilities in novel dental restoratives, or filling materials. According to the research, the resin-based composites, with the addition of antibacterial nano-assemblies, can hinder bacterial growth and viability on dental restorations, the main cause of recurrent cavities, which can eventually lead to root canal treatment and tooth extractions.

Research for the study was led by Dr. Lihi Adler-Abramovich and TAU doctoral student Lee Schnaider in collaboration with Prof. Ehud Gazit, Prof. Rafi Pilo, Prof. Tamar Brosh, Dr. Rachel Sarig and colleagues from TAU's Maurice and Gabriela Goldschleger School of Dental Medicine and George S. Wise Faculty of Life Sciences. It was published in ACS Applied Materials & Interfaces on May 28.

"Antibiotic resistance is now one of the most pressing healthcare problems facing society, and the development of novel antimicrobial therapeutics and biomedical materials represents an urgent unmet need," says Dr. Adler-Abramovich. "When bacteria accumulate on the tooth surface, they ultimately dissolve the hard tissues of the teeth. Recurrent cavities — also known as secondary tooth decay — at the margins of dental restorations results from acid production by cavity-causing bacteria that reside in the restoration-tooth interface."

This disease is a major causative factor for dental restorative material failure and affects an estimated 100 million patients a year, at an estimated cost of over $30 billion.

Historically, amalgam fillings composed of metal alloys were used for dental restorations and had some antibacterial effect. But due to the alloys' bold color, the potential toxicity of mercury and the lack of adhesion to the tooth, new restorative materials based on composite resins became the preferable choice of treatment. Unfortunately, the lack of an antimicrobial property remained a major drawback to their use.

"We've developed an enhanced material that is not only aesthetically pleasing and mechanically rigid but is also intrinsically antibacterial due to the incorporation of antibacterial nano-assemblies," Schnaider says. "Resin composite fillings that display bacterial inhibitory activity have the potential to substantially hinder the development of this widespread oral disease."

The scientists are the first to discover the potent antibacterial activity of the self-assembling building block Fmoc-pentafluoro-L-phenylalanine, which comprises both functional and structural subparts. Once the researchers established the antibacterial capabilities of this building block, they developed methods for incorporating the nano-assemblies within dental composite restoratives. Finally, they evaluated the antibacterial capabilities of composite restoratives incorporated with nanostructures as well as their biocompatibility, mechanical strength and optical properties.

"This work is a good example of the ways in which biophysical nanoscale characteristics affect the development of an enhanced biomedical material on a much larger scale," Schnaider says.

"The minimal nature of the antibacterial building block, along with its high purity, low cost, ease of embedment within resin-based materials and biocompatibility, allows for the easy scale-up of this approach toward the development of clinically available enhanced antibacterial resin composite restoratives," Dr. Adler-Abramovich says.

The researchers are now evaluating the antibacterial capabilities of additional minimal self-assembling building blocks and developing methods for their incorporation into various biomedical materials, such as wound dressings and tissue scaffolds.




Latest News

Early Humans Used Tiny, Flint "Surgical" Tools to Butcher Elephants

New discovery by TAU-led research group suggests early humans in the Levant were sophisticated and environmentally conscious.

TAU Ranks Among Top 10 Undergraduate Programs Producing Most Venture Capital-Backed Entrepreneurs

Joining Stanford, UC Berkeley, and MIT, TAU is the only non-U.S. university to make top 10 of global VC list.

Protein Mapping Pinpoints Why Most Metastatic Melanoma Patients Do Not Respond to Immunotherapy

Lipid metabolism found to affect cancer cells' visibility to the immune system, say TAU, Sheba Medical Center researchers.

Breakdown in Coral Spawning Places Species at Risk of Extinction

Synchronized coral spawning has become erratic, endangering the long-term survival of coral species, TAU researchers say.

Joanna Naftali Named Associate Vice President, Midwest of AFTAU

Accomplished fundraiser has deep roots in educational, philanthropic, and arts sectors.

Blocking Inflammatory Pathway Key to Preventing Brain Metastasis from Melanoma

Tumor cells "hijack" their way to the brain through an inflammatory factor secreted by brain cells, say TAU researchers.

TAU and Technion Researchers Wrest Control of One of World's Most Secure PLCs

Rogue engineering station instigated "hostile intervention" of Siemens programmable logic controller that runs industrial processes.

Novel Immunotherapy May Prevent Brain Metastases

Injection of synthetic DNA material found to activate brain's immune cells and kill invading tumor cells, TAU researchers say.

TAU Scientists Develop Novel Nano-Vaccine for Melanoma

Injection of nanoparticle has proven effective in mouse models, researchers say.

Genetic Screen Identifies Genes That Protect Cells from Zika Virus

Genes found to safeguard against infection as well as resuscitate infected cells, TAU researchers say.

contentSecondary
c

© 2019 American Friends of Tel Aviv University
39 Broadway, Suite 1510 | New York, NY 10006 | 212.742.9070 | info@aftau.org
Privacy policy | Tel Aviv University