Register for updates

 
 

Medicine & Health
RSS Feed
Novel Nanomedicine Inhibits the Progression of Pancreatic Cancer in Mouse Models, TAU Researchers Say
Tuesday, January 02, 2018 9:57:00 AM

Survival rates in pancreatic cancer linked to inverse correlation between specific oncogene and tumor suppressant

A new Tel Aviv University study pinpoints the inverse correlation between a known oncogene — a gene that promotes the development of cancer — and the expression of an oncosuppressor microRNA as the reason for extended pancreatic cancer survival. The study may serve as a basis for the development of an effective cocktail of drugs for this deadly disease and other cancers.

The study, which was published in Nature Communications, was led by Prof. Ronit Satchi-Fainaro, Chair of the Department of Physiology and Pharmacology at TAU's Sackler Faculty of Medicine, and conducted by Hadas Gibori and Dr. Shay Eliyahu, both of Prof. Satchi-Fainaro's multidisciplinary laboratory, in collaboration with Prof. Eytan Ruppin of TAU's Computer Science Department and the University of Maryland and Prof. Iris Barshack and Dr. Talia Golan of Chaim Sheba Medical Center, Tel Hashomer.

Pancreatic cancer is among the most aggressive cancers known today. The overwhelming majority of pancreatic cancer patients die within just a year of diagnosis. "Despite all the treatments afforded by modern medicine, some 75% of all pancreatic cancer patients die within 12 months of diagnosis, including many who die within just a few months," Prof. Satchi-Fainaro says.

"But around seven percent of those diagnosed will survive more than five years. We sought to examine what distinguishes the survivors from the rest of the patients," Prof. Satchi-Fainaro continues. "We thought that if we could understand how some people live several years with this most aggressive disease, we might be able to develop a new therapeutic strategy."

Calling a nano-taxi

The research team examined pancreatic cancer cells and discovered an inverse correlation between the signatures of miR-34a, a tumor suppressant, and PLK1, a known oncogene. The levels of miR-34a were low in pancreatic cancer mouse models, while the levels of the oncogene were high. This correlation made sense for such an aggressive cancer. But the team needed to see if the same was true in humans.

The scientists performed RNA profiling and analysis of samples taken from pancreatic cancer patients. The molecular profiling revealed the same genomic pattern found earlier in mouse models of pancreatic cancer.

The scientists then devised a novel nanoparticle that selectively delivers genetic material to a tumor and prevents side effects in surrounding healthy tissues.

"We designed a nanocarrier to deliver two passengers: (1) miR-34a, which degrades hundreds of oncogenes; and (2) a PLK1 small interfering RNA (siRNA), that silences a single gene," Prof. Satchi-Fainaro says. "These were delivered directly to the tumor site to change the molecular signature of the cancer cells, rendering the tumor dormant or eradicating it altogether.

"The nanoparticle is like a taxi carrying two important passengers," Prof. Satchi-Fainaro continues. "Many oncology protocols are cocktails, but the drugs usually do not reach the tumor at the same time. But our 'taxi' kept the 'passengers' — and the rest of the body — safe the whole way, targeting only the tumor tissue. Once it 'parked,' an enzyme present in pancreatic cancer caused the carrier to biodegrade, allowing the therapeutic cargo to be released at the correct address — the tumor cells."

Improving the odds

To validate their findings, the scientists injected the novel nanoparticles into pancreatic tumor-bearing mice and observed that by balancing these two targets — bringing them to a normal level by increasing their expression or blocking the gene responsible for their expression — they significantly prolonged the survival of the mice.

"This treatment takes into account the entire genomic pattern, and shows that affecting a single gene is not enough for the treatment of pancreatic cancer or any cancer type in general," according to Prof. Satchi-Fainaro.

Research for the study was funded by the European Research Council (ERC), Tel Aviv University's Cancer Biology Research Center (CBRC) and the Israel Science Foundation (ISF).




Latest News

Brain Arousal Compound Noradrenaline Plays Critical Role in Sensory Perception

Discovery paves way for detecting situations of dangerous lapses and for improving anesthesia protocols, TAU researchers say.

Compounds Found in Green Tea and Wine May Block Formation of Toxic Metabolites

Discovery may pave the way for therapies to treat inborn congenital metabolic disorders, TAU researchers say.

2018 Tel Aviv International Student Film Festival Celebrates Women in Cinema

Twentieth edition of festival draws film students and distinguished Israeli and international directors.

Smart Probe Detecting Cancer Cells May Improve Survival Rates

Fluorescent tags of injected polymers are "turned on" by an enzyme overproduced in cancer cells, TAU researchers say.

The Steinhardt Museum of Natural History at TAU to Open July 2018

New museum displays thousands of items that tell the story of biodiversity in Israel and the Middle East.

Modern Laser Science Brightened by 2,300-Year-Old Technology

Archimedes' screw inspires TAU researchers to devise a novel particle-trapping laser beam.

Neuronal Activity Sheds Light on the Origin of Consciousness

Electrodes in patients with epilepsy register neuronal activity underlying emergence of conscious experience, TAU researchers say.

Philadelphia Orchestra Performs with TAU Students, Israel Philharmonic in Packed Concert

Orchestra's trip to Israel is the third visit to the country by a major U.S. symphony orchestra.

TAU Student Film Wows at Cannes Film Festival

Rubber Dolphin written and directed by Steve Tisch School of Film and Television graduate.

Changes to Specific MicroRNA Involved in Development of Lou Gehrig's Disease

Mechanism involving specific microRNA and muscle molecules plays role in amyotrophic lateral sclerosis, TAU researchers say.

contentSecondary
c

© 2018 American Friends of Tel Aviv University
39 Broadway, Suite 1510 | New York, NY 10006 | 212.742.9070 | info@aftau.org
Privacy policy | Tel Aviv University