Musical tests can detect mental deterioration in old age
TAU method enables routine monitoring and early detection of cognitive declineSupport this research
Researchers at Tel Aviv University (TAU) have developed a method that employs musical tests and a portable instrument for measuring brain activity to detect cognitive decline in old age. According to the researchers, the method, which is based on the measurement of 15 minutes of electrical activity in the brain while performing simple musical tasks, can be easily implemented by any staff member in any clinic, without requiring special training.
“Our method enables routine monitoring and early detection of cognitive decline in order to provide treatment and prevent rapid, severe deterioration,” the researchers say. “Prophylactic tests of this kind are commonly accepted for a variety of physiological problems such as diabetes, high blood pressure, or breast cancer; however, to date no method has yet been developed to enable routine, accessible monitoring of the brain for cognitive issues.” The researchers further note that tests of this kind are particularly important in light of increasing longevity and associated growth of the elderly population.
The study was led by PhD student Neta Maimon of TAU’s School of Psychological Sciences and Buchmann-Mehta School of Music, and Lior Molcho from Neurosteer Ltd, headed by Professor Nathan Intrator of TAU’s Blavatnik School of Computer Science and Sagol School of Neuroscience. The research was published on May 30, 2022, in the journal Frontiers in Aging Neuroscience.
As part of the study, the researchers developed a groundbreaking method that combined a portable device developed by Neurosteer for the measurement and innovative analysis of electroencephalography (EEG), and a short musical test of about 12-15 minutes, developed by Maimon. During the test, the subject is connected to the portable EEG device by means of a adhesive band with only three electrodes attached to the forehead. The subject performs a series of musical-cognitive tasks according to audible instructions given through earphones. The tasks include short melodies played by different instruments, with the subjects instructed to perform various tasks on them at varying levels of difficulty — for example, pressing a button each time any melody is played or pressing it only when the violin plays. In addition, the test includes several minutes of musically guided meditation designed to bring the brain to a resting state, as this state is known to indicate cerebral functioning in various situations.
Maimon, who specializes in musical cognition, explains that music has great influence on different centers in the brain. On the one hand, music is known to be a quick mood stimulant, particularly of positive emotion. On the other hand, in different situations, music can be cognitively challenging, activating the frontal parts of the brain, especially if the listener tries to concentrate on different aspects of the music, and at the same time perform a particular task. As a result, cognitive tests can be created that are quite complex, yet also pleasant and easy to perform. Furthermore, music that is positive and reasonably rhythmic will enhance concentration and performance of the task.
Accordingly, the researchers hypothesized that with musical tools, it would also be possible to challenge the subjects to an extent that would enable testing of the brain’s frontal activity as well as raising their spirits, thus enhancing their performance on the test while the overall experience is pleasant.
The study included an experiment at the Dorot-Netanya Geriatric Medical Center. “Anyone hospitalized at Dorot, or any other geriatric rehabilitation institution, undergoes a standard test called ‘mini-mental,’ designed to evaluate their cognitive condition as a routine part of the intake process,” Maimon says. “The test is conducted by an occupational therapist specially trained for it, and includes a variety of tasks. For example, enumerating the days of the week or months of the year backwards. In this test, up to 30 points can be accrued. A high score indicates normal cognition.”
The experiment included the testing of 50 elderly people hospitalized at Dorot who scored 18-30 on the mini-mental test, indicating various levels of cognitive functioning. The participants performed the musical-cognitive tasks. The EEG device registered the electrical activity in the brain during the activity, with the results analyzed using machine learning technology. This allowed mathematical indices to be identified that were precisely correlated with the mini-mental test scores; in other words, new neuro-markers (brain markers) could be obtained that may stand alone as indices of the subject’s cognitive status.
“We have actually succeeded in illustrating that music is indeed an effective tool for measuring brain activity,” Maimon says. “The brain activity and response times to tasks correlated to the subjects’ cerebral conditions (correlating to the mini-mental score assigned to them). More importantly, all those who underwent the experiment reported that, on the one hand, it challenged the brain, but on the other it was very pleasant to perform.”
“Our method enables the monitoring of cognitive capability and detection of cognitive decline already in the early stages, all by simple and accessible means, with a quick and easy test that can be conducted in any clinic,” the researchers conclude. “This method is of special importance today due to the increase in longevity and accelerated population growth, particularly among the elderly. Today, millions of people around the world already suffer or are liable to suffer soon from cognitive decline and its dire consequences, and their number will only increase in the coming decades. Our method could pave the way towards efficient cognitive monitoring of the general population, and thus detect cognitive decline in its early stages, when treatment and prevention of severe decline are possible. It is therefore expected to improve the quality of life of millions around the world.”
Keren Primor Cohen, CEO of Ramot at TAU, says, “We are pleased that a company based on a technology developed at TAU continues its collaboration on creative and multidisciplinary research. Ramot will continue to promote and invest in novel technologies, as well as help TAU researchers to maximize their research’s potential.”